Explore the fascinating world of fish respiration in this Bidder Lecture from the SEB Gothenburg 2017 conference. Delve into the mechanisms and reasons behind breathing control in fish, presented by Steve Perry from the University of Ottawa, Canada. Learn about the benefits of hyperventilation, the role of neuroepithelial cells in sensing CO2 and ammonia, and the involvement of Rhesus glycoproteins in ammonia sensing. Discover how hypoxia-inducible factor 1-alpha (HIF1a) regulates the hypoxic ventilatory response and its potential connection to nitric oxide. Examine the crucial role of serotonin in chemoreception and its impact on the hypoxic ventilatory response in fish. Gain insights into cutting-edge research techniques, including studies on zebrafish larvae, that are advancing our understanding of fish respiratory physiology.
Overview
Syllabus
The Control of Breathing in Fish - Why and How
George Parker Bidder III (1863-1953)
George Bidder III saves the day!
The world record!
A remarkable man!
Sensing the environment
What is the benefit of hyperventilation?
Empirical evidence for beneficial effects of hyperventilation
Benefits of hyperventilation
Functional studies of gill neuroepithelial cells
Neuroepithelial cells are CO2 sensors
Neuroepithelial cells are ammonia sensors
Rhesus (Rh) glycoproteins and ammonia sensing
HEA causes hyperventilation in larval zebrafish
Are Rh proteins involved?
Rh protein localisation in
in zebrafish larvae
A proposed model for ammonia sensing in zebrafish
Does HIF1a regulate the hypoxic hyperventilatory response?
HVR in wildtype larval zebrafish
HVR in larval zebrafish
Is the stimulatory effect of HIFla on the hypoxic ventilatory response related to nitric oxide?
HIF1a and nitric oxide
The role of 5-HT in chemoreception
Serotonin synthesis
TPH1a knockdown reduces number of detectable NECS
Depletion of NEC serotonin blunts the hypoxic ventilatory response
A model for the involvement of serotonin in chemoreception
Final words
Taught by
Society for Experimental Biology
