Engineering Selective Covalent Ligands for Diverse Applications in Biology

Explore the cutting-edge research in chemical biology presented by Dr. Matt Bogyo from Stanford University in this seminar from the Broad-MIT Seminars in Chemical Biology series. Delve into the development of covalent binding small molecule probes using advanced techniques like phage and mRNA display. Learn about the applications of these chemical tools in monitoring enzyme activities for diagnostic purposes, imaging, and drug discovery. Discover the latest advances in protease activated fluorescent probes for real-time tumor visualization during surgery and the identification of novel serine hydrolases in pathogenic and commensal bacteria. Gain insights into potential imaging and therapy targets that could disrupt bacterial colonization and community formation within hosts. Understand the implications of this research for cancer and infectious disease studies, funded by NIH grants.