Learn about Isaac Newton's remarkable scientific achievements during the Great Plague of 1665-1666, when he was forced to leave Cambridge University and work in isolation at his family estate in Woolsthorpe. Explore how this period of quarantine became Newton's "annus mirabilis" (miracle year), during which he developed groundbreaking theories in calculus, optics, and gravity. Discover the parallels between Newton's time of isolation and modern experiences with quarantine, while gaining insights into how periods of solitude can foster extraordinary creativity and scientific breakthroughs.